Response of Booster Dose of Cuban Recombinant Hepatitis-b Vaccine in Nonresponder and Hyporesponder Children

Background: Acute hepatitis B infection can debilitate a patient for weeks and occasionally has a fatal outcome, while chronic infection is a major threat to the individual. Objective: To assess response of nonresponder and hyporesponder children to booster dose of Cuban recombinant hepatitis B vaccine. Subjects and Methods: An interventional, descriptive study has been conducted on children who had been immunized with Cuban recombinant Hepatitis B vaccine and their antibody titers were <10mIU/ml (nonresponder) and 10-100mIU/ml (hyporesponder) administered booster dose of the same vaccine in their Deltoid muscles. Results: The response of 141 children with the mean age of 1.9 years to booster dose of vaccine were 94.3% and 100% vaccinees with the first and second booster dose of vaccination respectively. The anti-HBs titer in nonresponders and hyporesponders were 468±346 and 783± 346mIU/ml respectively with significant differences between two groups (P=0.001). Conclusion: This study demonstrate moderately increase antibody production in the majority of vaccinees with single supplementary vaccine.